Scientists of Osaka Dental University researched
Studies showed implant osseointegration is affected by surface wettability. The relationship between hydrophilicity and cell adhesion has been confirmed in vivo studies. Concentrated alkali improves the biocompatibility of pure titanium. In this study, we used piezobrush® PZ2 to coat the disks by using active gas in atmospheric-pressure, low-temperature plasma treatment processing, to enhance the hydrophilicity of the material surface. The aim was to assess its influences on the initial adhesion of the material to rat bone marrow and subsequent differentiation into hard tissue. No structural change and a decrease in contact angle was observed. The treated samples had higher values for in vitro bovine serum albumin adsorption, rat bone marrow cell initial adhesion, alkaline phosphatase activity activity tests, and factors related to bone differentiation than the untreated control. The present study indicated that the induction of superhydrophilicity in titanium via atmospheric pressure plasma treatment with a piezobrush affects RBM cell adhesion and bone differentiation without altering surface properties.